Sant'Orsola Church was built for the 'Compagnia di Sant'Orsola' (Brotherhood of Saint Ursula), a group of believers which was founded in 1564 in the neighbouring church of Santi Quaranta Martiri Pisani al Casalotto.
The church was open to the public in 1662. The nave, and maybe the entire building, was designed by Giacomo Amato. In 1672 a beautification work started. During this period the building was decorated with stuccos and paintings. In the following century another beautification work was made. As a result of these actions, the church houses several artworks of important Sicilian artists.
References:The first written record of church in Danmark locality date back to the year 1291. Close to the church are several stones with a Christian text and cross inscribed. The oldest parts of the present red-brick church are from the 1300s. In the late 1400s the church was enlarged to the appearance it has today. The church has been modified both internally and externally several times, among other things after the fires in 1699 and 1889. There are lot of well-preserved mural paintings in the walls.