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The area surrounding Nafplio has been inhabited since ancient times, but few signs of this, aside from the walls of the Acronauplia, remain visible. Subsequently, Byzantines, Franks, Venetians, and Turks added to the fortifications. It became a place of considerable importance, and has continued so down to the present day. In the time of the Crusades it first emerges from obscurity. Nafplio was taken in 1212 by French Crusaders of the Principality of Achaea. It became part of the lordship of Argos and Nauplia, which in 1388 was sold to the Republic of Venice, who regarded it as one of their most important places in the Levant. During the subsequent 150 years, the lower city was expanded and fortified, and new fortifications added to Acronauplia.
The Basilica of Santa Maria in Trastevere is one of the oldest churches of Rome. The basic floor plan and wall structure of the church date back to the 340s, and much of the structure to 1140-43. The first sanctuary was built in 221 and 227 by Pope Callixtus I and later completed by Pope Julius I.
The inscription on the episcopal throne states that this is the first church in Rome dedicated to Mary, mother of Jesus, although some claim that privilege belongs to the Basilica di Santa Maria Maggiore. A Christian house-church was founded here about 220 by Pope Saint Callixtus I (217-222) on the site of the Taberna meritoria, a refuge for retired soldiers. The area was made available for Christian use by Emperor Alexander Severus when he settled a dispute between the Christians and tavern-keepers.
The church underwent two restorations in the fifth and eighth centuries and in 1140-43 it was re-erected on its old foundations under Pope Innocent II.