Sant'Anastasia curch was built between the late 3rd and early 4th century, possibly by a Roman woman named Anastasia. The church is listed under the titulus Anastasiae in the acts of the 499 synod. Later the church was entitled to the martyr with the same name, Anastasia of Sirmium.
The church was restored several times: Pope Damasus I (366-383), Pope Hilarius (461-468), Pope John VII (705-707), Pope Leo III (795-816), and Pope Gregory IV (827-844). The current church dates back to the 17th century restoration commissioned by Pope Urban VII.
Traditionally, the church is connected to the cult of St Jerome, who possibly celebrated mass here. The saint is depicted over the altar, by Domenichino.
The last restoration, after the restoration during the papacy of Sixtus IV, occurred in 1636, when the facade, with lower doric and upper ionic order, was reconstructed in 1636, after the cyclone of 1634. The nave recycles antique columns. The ceiling is frescoed with a martyrdom of the saints (1722) by Michelangelo Cerruti.
The chapel to the right, has a painting of St. John the Baptist by Pier Francesco Mola. The right transept has a painting of S.Toribio (1726) by Francesco Trevisani. The high altar has a Nativity by Lazzaro Baldi and below the altar is a statue of Saint Anastasia by Ercole Ferrata. It clearly shows the influence of Bernini's Beata Ludovica Albertoni. The left transept has a Madonna of the Rosary by Baldi, and the tomb of Cardinal and philologist Angelo Mai by the late neoclassical sculptor Giovanni Maria Benzoni. The last chapel to the left, by Domenichino depicts a St. Jerome. The other chapel has a Ss.Giorgio e Publio by Etienne Parrocel.
References:Manarola is a small town, a frazione of the comune of Riomaggiore. It is the second-smallest of the famous Cinque Terre towns frequented by tourists, with a population of 353.
Manarola may be the oldest of the towns in the Cinque Terre, with the cornerstone of the church, San Lorenzo, dating from 1338. The local dialect is Manarolese, which is marginally different from the dialects in the nearby area. The name 'Manarola' is probably a dialectical evolution of the Latin, 'magna rota'. In the Manarolese dialect this was changed to 'magna roea' which means 'large wheel', in reference to the mill wheel in the town.
Manarola's primary industries have traditionally been fishing and wine-making. The local wine, called Sciacchetrà, is especially renowned; references from Roman writings mention the high quality of the wine produced in the region.