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The Franciscan order arrived in Brescia around 1220, after a visit to the city by the founder himself. Construction of the convent structures began around 1254 and continued for over a century. The cloister of the adjacent Convent, designed by Guglielmo da Frisone, was completed in 1394.
In the 14th century, it is likely the entire walls and ceilings were frescoed, but the creation of chapels and other restorations covered much of this work except for traces behind the 2nd and third altars. The Crucifixion fresco in the 2nd chapel on the left dates to 1310-1320. On the right, the chapel dedicated to St Jerome has decorative sculpture (1506) by Gasparo da Coirano. Other internal decoration was by Ottavio Viviani, Pietro Ricchi (il Lucchese), and Gian Giacomo Barbello.
The Franciscan order's residence in the monastery was suppressed during Napoleonic rule, only for them to return later in the 19th century. The structure still houses monks from the order.
References:The first written record of church in Danmark locality date back to the year 1291. Close to the church are several stones with a Christian text and cross inscribed. The oldest parts of the present red-brick church are from the 1300s. In the late 1400s the church was enlarged to the appearance it has today. The church has been modified both internally and externally several times, among other things after the fires in 1699 and 1889. There are lot of well-preserved mural paintings in the walls.